We are a catalysis and synthesis group with particular interest in the following areas:
1. Gold Catalysis
In the past decade, gold has emerged as a powerful catalyst for the electrophilic activation of carbon-carbon π bonds. Gold catalysis represents a new frontier in catalysis with scope for further discoveries and development, particularly in the field of asymmetric gold catalysis. We are interested in the development of novel gold catalysed reactions with the aim of expanding the current toolkit of synthetic techniques. Recent highlights from our group include developing novel gold-catalysed reactions with cyclopropenes, allenes and allylic alcohols.
For representative publications, see: ACS Catal., 2019, 9, 2552. Abstract; Chem. Eur. J., 2018, 24, 7002. Abstract; Chem. Eur. J., . Article; Chem. Eur. J. 2016, 22, 18593. Article; Chem. Eur. J., 2015, 21, 13748. Article; J. Org. Chem., 2015, 80, 9807. Article; Chem. Commun., 2013, 49, 4262. Abstract; Org. Lett., 2012, 14, 898. Abstract; Chem. Commun.,2011, 47, 1333. Abstract; Org. Lett. 2010, 12, 484. Abstract; Chem. Commun., 2008, 6405. Abstract
2. Dual Metal- and Photoredox-Catalysis
We have recently developed dual gold- and photoredox-catalysed methods for cross couplings through C-H activation or transmetallations. For representative publications, see: Chem. Sci. 2017, 8, 2885. Article; Chem. Commun. 2016, 52, 10163. Article.
For our recent review on dual copper and photoredox-catalysed reactions, see: Tetrahedron, 2018, 74, 4881. Abstract.
3. Palladium Catalysis
We have recently developed a mild and ligand free cationic Pd(II) system for conjugate additions to hindered γ-substituted cyclohexenones. We have also developed a ligand- and base-free Pd(II)-Catalysed Controlled Switching between oxidative Heck and conjugate addition reactions, and controlled C-H functionalisations of benzoquinones. Current work in the group centres around the development and further applications of the cationic Pd(II) system as well as enantioselective Pd(II) reactions.
For representative publications: Chem. Eur. J., 2017, 23, 18282. Article; Chem. Commun, 2015, 51, 4089. Article; Angew. Chem. Int. Ed., 2014, 53, 13876. Article; Org. Lett.,2013, 15, 1886. Abstract; Org. Lett., 2012, 14, 2508. Abstract. Review: Org. Biomol. Chem., 2016, 14, 5357. Article.
4. New gold catalysts:
Mesoionic N-Heterocyclic Carbene (NHC) Complexes
In collaboration with Dr James Crowley (University of Otago), we are studying novel gold(I) ‘‘click’’ carbene(1,2,3-triazolylidene) complexes and their applicationsin catalysis. For representative publication, see: Chem. Commun., 2011, 47, 328. Abstract; Organometallics., 2013, 32, 7065-7076. Article and review: Aust. J. Chem. 2011, 64, 1118. Abstract
For representative publication, see: Catal. Sci. Technol., 2012, 2, 1818. Abstract
Deactivation of catalysts
For representative publication, see: see: Dalton Trans., 2013, 42, 9645-9653. Abstract
5. Chiral rotaxanes
One of the most interesting and yet least exploited features of rotaxanes is chirality - a rotaxane consisting of an asymmetric rotor and asymmetric axis can have cyclochirality, even if both the rotor and axis are themselves achiral. To date, there are no efficient methods for the catalytic enantioselective synthesis of cyclochiral rotaxanes. We are interested in tackling this challenging problem using tools from the field of asymmetric catalysis. For representative publication: Tetrahedron, 2013, 67, 57-68, abstract.