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Lee Group Publications
  • "Dual Gold and Photoredox Catalysed C-H Activation of Arenes for Aryl-Aryl Cross Couplings " V. Gauchot, D. R. Sutherland, A.-L. Lee, Chem. Sci. 2017, 8, 2885-2889 Open Acces.

  • "Chirality Transfer in Gold(I)-Catalysed Hydroalkoxylation of 1,3-Disubstituted Allenes" S. Webster, D. R. Sutherland, A.-L. Lee, Chem. Eur. J. 2016, 22,  18593–18600. Open Access.

  • "Dual Gold Photoredox C(sp2)-C(sp2) Cross Couplings – Development and Mechanistic Studies" V. Gauchot, A.-L. Lee, Chem. Commun. 2016, 52, 10163. Open Access.

  • “Enantioselective Oxidative Boron Heck Reactions” A.-L. Lee, Org. Biomol. Chem., 2016, 14, 5357. Abstract
    • Invited Review Article: New Talent Special Issue

  • “A Rotaxane with a Golden Touch” A.-L. Lee, Nature Chem., 2016, 8, 8. Article
    • Invited "News and Views" article discussing a new gold-rotaxane catalyst by the Goldup Group.

  • “Indium vs. Gold Catalysis in Dehydrative Reactions with Allylic Alcohols” S. Webster, L. Schaefer, G. Barker, A.-L. Lee, Synlett, 2015, 26, 2673. Abstract
    • Invited Article: Young Investigators Workshop - SYNLETT Special Issue

  • “Chirality Transfer in Gold(I)-Catalysed Direct Allylic Etherification of Unactivated Alcohols - Experimental and Computational Study” G. Barker, D. G. Johnson, P. C. Young, S. A. Macgregor, A.-L. Lee, Chem. Eur. J., 2015, 21, 13748. Open Access

  • “Gold-Catalyzed Proto- and Deutero-deboronation” G. Barker, S. Webster, D. G. Johnson, R. Curley, M. Andrews, P. C. Young, S. A. Macgregor, A.-L. Lee, J. Org. Chem, 2015, 80, 9807. Open Access
    • Cover and Featured Article, Issue 20.
    • Highlighted in Synfacts 2015, 11, 1093, Contributors: P. Knochel and D. Haas. Abstract
    • Highlighted in Organic Chemistry Portal abstracts.

  • “Oxidative Heck Desymmetrisation of 2,2-Disubstituted Cyclopentene-1,3-diones” S. E. Walker, C. J. C. Lamb, N. A. Beattie, P. Nikodemiak, A.-L. Lee, Chem. Commun., 2015, 51, 4089-4092. Open Access Article

  • “Dehydrative Thiolation of Allenols - Indium vs. Gold Catalysis” S. Webster, P. C. Young, G. Barker, G. M. Rosair, A.-L. Lee, J. Org. Chem., 2015, 80, 1703-1708.  Abstract.

  • “Pd-Catalyzed Direct C-H Functionalization of Benzoquinone” S. E. Walker, J. A. Jordan-Hore, D. G. Johnson, S. A. Macgregor, A.-L. Lee, Angew. Chem. Int. Ed., 2014, 53, 13876-13879. Open Access Article.

  • “Gold(I)-Catalysed Direct Thioetherifications using Allylic Alcohols - an Experimental and Computational Study” L. Herkert, S. L. J. Green, G. Barker, D. G. Johnson, P. C. Young, S. A. Macgregor, A.-L. Lee, Chem. Eur. J., 2014, 20, 11540-11548. Open Access Article.

  • "Gold(I) and Palladium(II) Complexes of 1,3,4-Trisubstituted 1,2,3-Triazol-5-ylidene Click Carbenes: Systematic Study of the Electronic and Steric Influence on Catalytic Activity", J. R. Wright, P. C. Young, N. T. Lucas, A.-L. Lee, J. D. Crowley, Organometallics., 2013, 32, 7065-7076. Open Access Article

  • "Deactivation of Gold(I) Catalysts in the Presence of Thiols and Amines - Characterisation and Catalysis", P. C. Young, S. L. J. Green, G. M. Rosair, A.-L. Lee, Dalton Trans., 2013, 42, 9645-9653. Open Access Article

  • “Ligand and Base-free Pd(II)-Catalyzed Controlled Switching between Oxidative Heck and Conjugate Addition Reactions”, S. E. Walker, J. Boehnke, P. E. Glen, S. Levey, L. Patrick, J. A. Jordan-Hore, A.-L. Lee, Org. Lett., 2013, 15, 1886-1889. Abstract.

  • "Organocatalyzed Carbonyl–Olefin Metathesis", A.-L. Lee, Angew. Chem. Int. Ed., 2013, 52, 4524. Abstract.
    • Invited Highlight on Lambert's carbonyl-olefin metathesis work

  • "Gold(I)-Catalysed Direct Allylic Etherification of Unactivated Alcohols", P. C. Young, N. A. Schopf, A.-L. Lee, Chem. Commun., 2013, 49, 4262-4264. Abstract.
    • Invited article: Emerging Investigators Special Issue, 2013.
    • "HOT" Article - available free of charge from Chem. Commun. website until 14th December 2012.
    • Read the Chem. Commun. blog about this work here.
    • Highlighted in Organic Chemistry Highlights, October 2013 on the Organic Chemistry Portal.

  • "Synthesis of a C1-Symmetric Box Macrocycle and Studies toward Active Template Synthesis of Mechanically Planar Chiral Rotaxanes", P. E. Glen, J. A. T. O'Neill, A.-L. Lee, Tetrahedron, 2013, 67, 57-68. Abstract.

  • "Gold(I)-Catalyzed Addition of Thiols and Thioacids to 3,3-Disubstituted Cyclopropenes", R. J. Mudd, P. C. Young, J. A. Jordan-Hore, G. Rosair, A.-L. Lee, J. Org. Chem., 2012, 77, 7633–7639 Abstract
  • ""Gold(III)-oxo complexes as catalysts in intramolecular hydroamination", J. A. T. O'Neill, G. M. Rosair, A.-L. Lee, Catal. Sci. Technol., 2012, 2, 1818-1821. Abstract

  • "Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones", J. A. Jordan-Hore, J. N. Sanderson, A.-L. Lee, Org. Lett., 2012, 14, 2508-2511. Abstract

  • "Computational Studies on the Mechanism of the Gold(I)-Catalysed Rearrangement of Cyclopropenes", M. S. Hadfield, L. J. Häller, A.-L. Lee, S. A. Macgregor, J. A. T. O'Neill, A. M. Watson, Org. Biomol. Chem., 2012, 10, 4433-4440. Abstract

  • "Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes", P. C. Young, M. S. Hadfield, L. Arrowsmith, K. M. Macleod, R. J. Mudd, J. A. Jordan-Hore, A.-L. Lee, Org. Lett., 2012, 14, 898-901. Abstract

  • "1,3,4-Trisubstituted-1,2,3-Triazol-5-ylidene ‘Click’ Carbene Ligands: Synthesis, Catalysis and Self-Assembly", J. D. Crowley, A.-L. Lee, K. J. Kilpin, Aust. J. Chem. 2011, 64, 1118–1132. Review in the ‘Research Front’ issue on N-heterocyclic carbenes. Abstract
    • Ranked top 5 "Most Read" based on number of downloads (July 2012)

  • "Enantioselective Catalysis", A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2011, 107, 369–389. Abstract

    - This review highlights significant advances in the field of enantioselective catalysis in 2010. Key advances in enantioselective gold-catalysed reactions, palladium-catalysed Heck reactions and alkene metathesis will be emphasised.

  • "Gold(I)-Catalysed Iodoalkoxylation of Allenes", A. Heuer-Jungemann, R. G. McLaren, M. S. Hadfield, A.-L. Lee, Tetrahedron, 2011, 67, 1609 - 1616. Abstract

  • "Gold(I)-catalysed Synthesis of Conjugated Trienes", M. S. Hadfield, A.-L. Lee, Chem. Commun., 2011, 47, 1333 - 1335. Abstract

  • "Gold(I) "Click" 1,2,3-Triazolylidenes: Synthesis, Self-assembly and Catalysis", K. J. Kilpin, U. S. D. Paul, A.-L. Lee, J. D. Crowley, Chem. Commun., 2011, 47, 328 - 330 (Emerging Investigators Theme Issue). Abstract

  • "Gold(I)-Catalysed Alcohol Additions to Cyclopropenes", M. S. Hadfield, J. T. Bauer, P. E. Glen, A.-L. Lee, Org. Biomol. Chem., 2010, 8, 4090 - 4095. Abstract

  • "Enantioselective Catalysis", A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2010, 106, 428-446. Abstract

    - This review highlights significant advances in the field of enantioselective catalysis in 2009. Key advances in enantioselective gold-catalysed reactions and alkene metathesis are emphasised.

  • "Regioselective Synthesis of tert-Allylic Ethers via Gold(I)-Catalyzed Intermolecular Hydroalkoxylation of Allenes", M. S. Hadfield, A.-L. Lee, Org. Lett., 2010, 12, 484-487. Abstract
    • Highlighted in Synfacts 2010, 0573, Contributors: H. Yamamoto and K. Griffin. Abstract

  • "Enantioselective Catalysis", A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2009, 105, 421-439. Abstract

    -This review highlights significant advances in the field of asymmetric synthesis, with a mechanistic and catalysis flavour. Since this is the first review in Annual Reports B on this series, major advances from 2008 as well as a few older papers are covered. Key advances in enantioselective Heck couplings, alkene metathesis and catalysis by interlocked architectures are emphasised.

  • "Gold Catalysed Reactions with Cyclopropenes", J. T. Bauer, M. S. Hadfield, A.-L. Lee, Chem. Commun., 2008, 6405-6407. Abstract

Publications from Ai-Lan's postdoctoral and PhD studies:

  • "Active metal template synthesis of rotaxanes, catenanes and molecular shuttles", J. D. Crowley, S. M. Goldup, A.-L. Lee, D. A. Leigh and R. T. McBurney, Chem. Soc. Rev., 2009, 38, 1530-1541. Abstract
  • "Cadiot-Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions", J. Berna, S.M. Goldup, A.-L. Lee, D. A. Leigh, M. D. Symes, G. Teobaldi and F. Zerbetto, Angew. Chem. Int. Ed., 2008, 47, 4392-4396. Abstract
  • "[2]Rotaxanes through Palladium Active-Template Oxidative Heck Cross-Couplings", J. D. Crowley, K. Haenni, A.-L. Lee, D. A. Leigh, J. Am. Chem. Soc., 2007, 129, 12092-12093. Abstract
    • Highlighted in Synfacts 2007, 1257, Contributors: T. M. Swager, B. VanVeller. Abstract
  • "A Catalytic Palladium Based Active-Metal Template Pathway to [2]Rotaxanes", J. Berna, J. D. Crowley, S. M. Goldup, K. Haenni, A.-L. Lee, D. A. Leigh, Angew. Chem. Int. Ed., 2007, 46, 5709-5713. Abstract
  • "Operationally Simple, Efficient and Diastereoselectvie Synthesis of Cis-2,6-Disubstituted-4-methylene Tetrahydropyrans Catalyzed by Triflic Acid", A. Puglisi A.-L. Lee, R. R. Schrock, A. H. Hoveyda, Org. Lett., 2006, 8, 1871-1874. Abstract
  • "Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centres through Catalytic Asymmetric Ring-Closing Metathesis", A.-L. Lee, S. Malcolmson, A. Puglisi, R. R. Schrock, A. H. Hoveyda, J. Am. Chem. Soc., 2006, 128, 5153-5157. Abstract
  • "Integrated Microwave Assisted Synthesis and Solid-Supported Reagents", I.R. Baxendale, A.-L. Lee and S.V. Ley. In Microwave Assisted Organic Chemistry. Ed. J. P. Tierney and P. Lidstrom, Blackwells, 2005, ISBN 1405115602. Link
  • "The Synthesis of the Anti-malarial Natural Product Polysphorin and Analogues Using Polymer-supported Reagents and Scavengers", A-L. Lee, S.V. Ley, Org. Biomol. Chem., 2003, 1, 3957-3966. Abstract
  • "Microencapsulation of Osmium Tetroxide in Polyurea", S.V. Ley, C. Ramarao, A.-L. Lee, N. Östergaard, S.C. Smith, I.M. Shirley, Org. Lett., 2003, 5, 185-187. Abstract
  • "A Concise Synthesis of Carpanone Using Solid-Supported Reagents and Scavengers", I.R. Baxendale, A.-L. Lee, S.V. Ley, J. Chem. Soc., Perkin Trans. 1, 2002, 1850-1857. Abstract
  • "A Polymer-supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds", I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett, 2002, 516-518. Abstract
  • "A Concise Synthesis of the Natural Product Carpanone Using Solid-Supported Reagents and Scavengers", I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett, 2001, 1482-1484; Errata, I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett, 2001, 2004. Abstract
  • "Polymer Supported Hydroxide", S.V. Ley, I.R. Baxendale and A.-L. Lee. In Electronic Encyclopedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, 2001. Abstract
 

 

 

 

 

 

 

The photo above is of the Forth Bridge in Edinburgh. All photos © Ai-Lan Lee.